�UCLA scientists have succeeded in fashioning unique nanoscale droplets that are a great deal smaller than a human cell and can potentially be exploited to deliver pharmaceuticals.
"What we found that was unexpected was within each oil droplet there was also a water droplet - a double emulsion," said Timothy Deming, professor and chair of the UCLA Department of Bioengineering and a member of both the California NanoSystems Institute (CNSI) at UCLA and UCLA's Jonsson Cancer Center. "We have a water droplet inside of an oil droplet, in water."
"The big challenge," Deming added, "was to make these double-emulsion droplets in the sub-100-nanometer size range with these properties and suffer them be stable. We have demonstrated we lavatory make these emulsions that are stable in this size mountain range, which no one has ever been able to do before. These bivalent nanoemulsions ar generally concentrated to form and very unstable, but ours ar very stable."
Emulsions are droplets of one liquified in some other liquid; the two liquids do not mix.
"This gives us a fresh tool, a new material, for drug delivery and anticancer applications," said Thomas G. Mason, a UCLA associate professor of alchemy and physical science who has been ahead research on nanoemulsions since he united UCLA five years agone. Mason, wHO holds UCLA's John McTague Career Development Chair, is also a member of the CNSI.
Deming and Mason get made nanoemulsions containing billions of two-fold nanodroplets. Their research, coverage on droplets smaller than 100 nanometers - the world's smallest double emulsions - appears in the Sept. 4 edition of the journal Nature and is presently online.
"If we consume water-soluble drugs, we can load them inside," Deming said. "If we have water-insoluble drugs, we crapper load them inside as well. We can give birth them simultaneously."
"Here, you effectively combine both types of dose molecules in the same delivery parcel," Mason aforesaid. "This approach could be used for a combination therapy where you want to deliver two drugs simultaneously at a fixed ratio into the like location."
It might be possible to insert a pharmaceutical inside a droplet and interject the droplet inside a cell, the scientists aforementioned. Could these droplets release their cargo inside a cell?
"We're working on it," said Deming, wHO designs and engineers molecules. "There's a pretty clear path on how to do that. There are still challenges for dose delivery, merely we have demonstrated the key first step, that we can make these double emulsions that ar stable in this size range."
The cargo could be a protein toxin that helps to kill the cadre. For exemplar, one coming might involve an antineoplastic drug in the rock oil and a toxin-protein in the water - two molecules trying to belt down the cubicle simultaneously. While a prison cell can develop resistance to a single drug, the combination approach shot can be more effective, the scientists said.
Deming and Mason caution that while this approach holds promise for fighting genus Cancer, there ar still many steps, and likely many years of research, earlier patients could be treated in this way. Clinical trials victimization this inquiry would in all likelihood be days off.
"We'll have to do a lot of fine-tuning, simply this feeler has a lot of advantages," Deming said. "The size of these is a braggy advantage. We have observed unique molecular features that can steady double emulsions. These ar promising, but it's early on, and there ar many shipway these can fail. But we should at least learn how to make better drug-delivery vehicles."
In future enquiry, Deming and Mason require to make sure the droplets tin harmlessly infix cells and release their cargo.
The nanodroplets could potentially be used in cosmetics, soaps and shampoos as well.
NanoPacific Holdings Inc. has licensed this nanodroplet engineering from UCLA to acquire and market the applied science in a variety of applications.
Deming's laboratory is trying to take some of the key features that make proteins special and put them into synthetic materials.
"Tim has these beautiful molecules that he rear design and customize," Mason said.
Deming saw Mason give a UCLA speak about round-eyed nanoemulsions in which Mason was covering nanoscale crude oil droplets in water victimization natural proteins; the deuce agreed to try to combine the advantages of their materials, and their collaboration was born. Both scientists aforesaid working together has been "fantastic."
Emulsions are a way of taking an oil, which doesn't mingle with h2O, and putt it in a water-friendly environment, where, dispersed as droplets, it behaves wish a fluid. Emulsions have complex properties and ar found in many products, including foods, plastics, cosmetics, oil and paints.
"In the emerging field of nanoemulsions, this research is a prominent step," Mason said.
As a graduate student at Princeton University in the early 1990s, Mason founded a theater called thermal microrheology that is right away used by scientists world-wide. Microrheology is a method for examining the viscosity and snap of soft materials, including liquids and emulsions, on a microscopical scale.
Co-authors on the Nature paper are leash author Jarrod A. Hanson, a UCLA graduate student in Deming's laboratory; Connie B. Chang and Sara M. Graves, both graduate students in Mason's science lab; and Zhibo Li, a postdoctoral scholar in Deming's laboratory. Deming received a grant from the international Human Frontiers of Science program (hTTP://www.hfsp.org/) to support Hanson's research.
For more entropy about Mason's research, impose http://www.chem.ucla.edu/dept/Faculty/Mason. For more entropy about Deming's research, inspect http://deming.seas.ucla.edu/.
The California NanoSystems Institute (CNSI) is an integrated research center in operation jointly at UCLA and UC Santa Barbara whose mission is to foster interdisciplinary collaborations for discoveries in nanosystems and nanotechnology; train the next generation of scientists, educators and technology leadership; and facilitate partnerships with industry, refueling economic development and the social welfare of California, the United States and the world. The CNSI was established in 2000 with $100 million from the state of California and an additional $250 million in federal research grants and industry financing. At the institute, scientists in the areas of biology, chemistry, biochemistry, natural philosophy, mathematics, computational science and engineering ar measuring, modifying and manipulating the building blocks of our world - atoms and molecules. These scientists benefit from an structured laboratory refinement enabling them to acquit dynamic enquiry at the nanoscale, leading to significant breakthroughs in the areas of wellness, energy, the environment and information engineering. For extra information, bring down http://www.cnsi.ucla.edu/.
The UCLA Henry Samueli School of Engineering and Applied Science, established in 1945, offers 28 academic and professional stage programs, including an interdepartmental graduate degree program in biomedical engineering. Ranked among the top 10 engineering schools at public universities nationwide, the school is home to seven multimillion-dollar interdisciplinary research centers, in space geographic expedition, wireless sensing element systems, nanotechnology, nanomanufacturing and nanoelectronics, all funded by federal and private agencies. For more than information, visit http://www.engineer.ucla.edu/.
UCLA is California's largest university, with an enrollment of nearly 37,000 undergraduate and graduate students. The UCLA College of Letters and Science and the university's 11 professional schools feature notable faculty and offer more than ccc degree programs and majors. UCLA is a national and ational loss leader in the breadth and quality of its academic, research, wellness care, cultural, continuing education Department and athletic programs. Four alumni and five faculty have been awarded the Nobel Prize.
Source: Phil Hampton
University of California - Los Angeles
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Sunday 7 September 2008
Thursday 28 August 2008
Mp3 music: Horacio Guarany
 Artist: Horacio Guarany: mp3 download Genre(s): Latin Horacio Guarany's discography:  Recital Year: Tracks: 12 At the age of 17, Argentinean singer/songwriter Horacio Guarany left Alto Verde, the place where the creative someone spent his puerility, looking for for the opportunity to get tortuous in the local music setting. While living in Buenos Aires, Guarany started singing at modest venues until the fortune to progress to a record came in 1957. That self-titled album was followed by 1958's Folklore De Gala. In 1961, Horacio Guarany was one of the first artists participating in Cordoba's National Folkloric Festival. During the following years, Horacio Guarany was consolidating his music life sentence history and seemly an actor, acquiring a role in the 1972 moving picture Si Se Calla El Cantor, followed by 1974's La Vuelta. After living in Spain, Guarany returned to Argentina in 1978, touring about the state, being acclaimed for his loyalty to light up up Argentinean folklore. Proving unitary of his many artistic sides, during 1992 and 1993, Horacio Guarany dedicated precious time to composition Las Cartas Del Silencio, El Loco De La Guerra, and Sapucay. |
Friday 8 August 2008
Last night of the Proms sees Elgar's 'Land of Hope and Glory' played without vibrato
When this year's BBC Proms climax with the traditional chorus of Elgar's 'Land of Hope and Glory', prommers expecting the traditional rousing sing-along could feel clearly disappointed.
For the first time in the Proms' 113-year history, the march - also known as Pomp and Circumstance March No.1 - is likely to be played without vibrato, an obscure and extreme performance style that lends an frozen tone to music and divides classic music fans into opponent camps.
Vibrato, a musical burden produced by a even pulsating change of pitch, is secondhand to bring expression and vocal-like qualities to instrumental music. On string instruments, the effect is created by the controlled vibration of the finger retention down the string.
'If the orchestra agree, as I hope and think they will, to my suggestion that we play one of Britain's most patriotic pieces as its composer intended, and then the last night of the Proms will sound strikingly different to always before,' said Sir Roger Norrington, one of Europe's ahead conductors and founder of the London Classical Players.
The use of vibrato in classical music has become a matter of passionate dispute. For much of the 20th century it was used almost endlessly in the performance of pieces from all eras from the Baroque ahead. In the Seventies, even so, Norrington light-emitting diode a movement claiming that vibrato was a modernistic fashion introduced at the turn of the century. Music composed before that date, he said, should be played unadorned.
The foreman conductor of one of Germany's most famous orchestras, the Stuttgart Radio Symphony Orchestra, Norrington has a history of provoking a passionate and polarised response among audiences. As a vociferous exponent of the controversial 'pure tone' or 'musical authenticity' movement, Norrington believes music should be played on period instruments and often at radically different speeds to the way it is commonly heard. But musicians and audiences ar now concerned that Norrington has taken his crusade too far. Norrington aghast Prom audiences last week by conducting a vibrato-less rendition of Elgar's Symphony No. 1, a small-arm written in 1908.
'Hearing this Romantic music played without vibrato tore my heart out. Norrington calls this a "fresh" plan of attack, but you can call anything "fresh" and it is silent disgusting,' said Raymond Cohen, a professor at the Royal College of Music wHO has light-emitting diode most of the preeminent chamber orchestras in Europe, as well as the Royal Philharmonic, the Philharmonia and the London Symphony. 'Elgar would have turned in his grave.'
Anthony Payne, a composer most noted for complementary both Elgar's Symphony No. 3 and Pomp and Circumstance March No. 6, is too critical. 'Roger has become fixated on this issue and I feel he has kaput too far,' he said. 'I would be interested to know how many informed music-lovers enjoyed his Prom rendition of Elgar's symphonic music. I think many would have persuasion it odd.' Sir Mark Elder, music director of the Hall� Orchestra who conducted the last night of the Proms in 1987 and 2006, agreed. 'Roger is a wonderful player, but he is possessed,' he said. 'I don't cerebrate a add up ban on vibrato is based on historical truth. Vibrato has always been there.'
Keith Harvey, a cellist formerly in the Gabrieli Quartet, went further. 'Roger is alienating a big part of the musical profession,' he aforesaid. 'He has been implausibly insulting about the professionalism of those who habit vibrato, while at the same time reducing the sound of his orchestra to that of a bad amateur performance, producing a effectual often referred to as "grade three failed".'
Norrington refuses to mince his views. 'Here come the ouches and squirms, the flurry and brouhaha,' he said. 'I was expecting it, I'm throwing a hand grenade at musicians who simply have to accept they must transform their way of playing if they are to play as composers intended.' He added: 'Vibrato can be amazingly destructive to an orchestral formulation. It is acoustic central heating.'
Norrington is backed by Sir Nicholas Kenyon, director of the BBC Proms until last year. He said: 'I thought his Elgar Prom was improbably powerful and I'm sure the programme he's chosen for the last night will sound fresh and distinctive. It will be unusual in the way of life the last night should be.'
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Tuesday 1 July 2008
Radiohead Releases Live Performance Video Collection
Radiohead [ tickets ] has released 10 live performances videos exclusively through Apple's iTunes store, according to a press release. The videos feature live renditions of songs from "In Rainbows" and the bonus CD included in its deluxe discbox edition. The videos were recorded at The Hospital studio in Covent Garden with the team from the band's longtime producer Nigel Godrich's "From the Basement" TV show.
Thursday 19 June 2008
Nature One 2005
Artist: Nature One 2005
Genre(s):
Trance
Discography:
Ronski Speed Live
Year: 2005
Tracks: 1
Paul Van Dyk Live
Year: 2005
Tracks: 1
Friday 13 June 2008
R. Kelly Trial To Proceed
The judge in R. Kelly's child pornography case has denied his lawyers request to delay the case, allowing the jury selection to proceed and the singer to finally be trialled 6-years after his initial arrest.Kelly is facing charges over a video, reportedly filmed in 2002, showing the 41-year-old allegedly having sex with a 14-year-old girl.The singer's lawyer, Ed Genson, requested the delay after an article appeared in the Chicago Sun-Times last Saturday (May 3), claiming that a "secret witness" states she had a three-way with the musician and the reportedly underage girl.Judge Vincent Gaughan made the decision to proceed barring all reporters from the courtroom during jury selection, which is set to resume on Monday at 9am according to WBBM Chicago.Photo courtesy of Jive.
Friday 6 June 2008
Diamond scores career first with No. 1 album
NEW YORK (Billboard) - With "Home Before Dark," Neil Diamond has landed his first chart-topping album. The Columbia release, debuting at No. 1 on the Billboard 200, got a big plug when Diamond appeared recently on "American Idol," bolstering its 146,000 first-week U.S. sales, according to Nielsen SoundScan.
Sunday 25 May 2008
Prince Harry - Prince Harry Minders Investigated For High-speed Chase
British royal PRINCE HARRY and his police minders are under investigation by U.K. authorities, after allegedly taking part in a high-speed chase to get to London's Boujis nightclub.
According to reports, the young prince was driving his black Audi R8 along the M4 motorway in Berkshire, England, followed by a team of protection officers in unmarked police cars.
However, 33-year-old Tim Williams found himself caught up in the 100 mile (106.9 kilometer)-per-hour chase when one of the security vehicles drove up behind him, forcing him to accelerate and change lanes just to make way for Prince Harry as he passed by in his sports car.
Williams has made an official complaint to local authorities, and bosses at Thames Valley Police station have confirmed they are looking into the incident.
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Wednesday 21 May 2008
Sunday 18 May 2008
Manic Street Preachers
Artist: Manic Street Preachers
Genre(s):
Rock
Rock: Pop-Rock
Other
ROck: Alternative
Alternative
Discography:
Send Away the Tigers
Year: 2007
Tracks: 10
Autumnsong Part. 2
Year: 2007
Tracks: 4
God Save the Manics
Year: 2005
Tracks: 3
Radio Experience
Year: 2004
Tracks: 13
Lifeblood
Year: 2004
Tracks: 12
Forever Delayed
Year: 2002
Tracks: 20
Know Your Enemy
Year: 2001
Tracks: 16
This Is My Truth Tell Me Yours
Year: 1999
Tracks: 13
Gold Against the Soul
Year: 1999
Tracks: 10
Generation Terrorists
Year: 1999
Tracks: 18
Everything Must Go
Year: 1996
Tracks: 12
The Holy Bible
Year: 1994
Tracks: 13
Dressed in glam wear, wearing away intemperate eyeliner, and shouting political ornateness, the Manic Street Preachers emerged from their hometown of Blackwood, Wales, in 1991 as soi-disant "Generation Terrorists." Fashioning themselves after the Clash and the Sex Pistols, the Manics were on a military mission, intending to reestablish revolution to tilt & roll at a time when Britain was henpecked by trancey shoegazers and faceless, trippy caustic house. Their self-consciously grievous image, left-winger leanings, crunching tough stone, and foreigner status made them favorites of the British euphony press and helped them build a rabidly dedicated following.
For much of the band's early life history, it was impossible to separate the rhetoric from the music and even from the members themselves -- the group's image was forever associated with lyricist/guitarist Richey James carving the words "4 Real" into his arm during an early interview. As the British down music climate shifted toward Britpop in the awaken of Suede, the Manics didn't accomplish fame, but they had ill fame. Legions of followers emerged, including many bands that formed the core of the transient "new wafture of new wave" move.
Just as the chemical group climbed toward stardom, the story didn't catch simpler -- it got weirder. James' behaviour became more and more flaky, culminating on the group's torturing 1994 record album The Holy Bible. Early in 1995, James disappeared, going no decipher of his whereabouts. The odd triad carried on with 1996's Everything Must Go, the album that established them as superstars in England, in time that came at the disbursement of the self-important, renegade gender-bending and revolutionary rhetoric that earned them their initial winnow base.
It was a freakish, unpredictable travel for a band that once announced that all bands should separate up after releasing one album. James Dean Bradfield (vocals, guitar), Nicky Wire (natural Nick Jones; bass part), Sean Moore (drums), and Flicker (regular recurrence guitar) formed Betty Blue in 1986. Within two years' time, Flicker had left wing the dance orchestra and the group had changed its name to the Manic Street Preachers. In the summer of 1988, a mate scholar of Wire's at Swansea University, Richey James (natural Richey Edwards), wHO had been the group's driver, linked the band as calendar method of birth control guitar player. They began recording demos, finally cathartic the exclusive "Suicide Alley" in August. "Felo-de-se Alley" boasted a cover replicating that of the Clash's first album, which indicated the sound of the chemical group at the time -- equate parts punk and hard rock-and-roll. A year after the single's release, the NME gave it an enthusiastic inspection, citing James' press release -- "We are as far away from anything in the '80s as possible."
Indeed, the Manics were one of the key bands of the early '90s, and their vocation didn't get rolling until 1991. The Fresh Art Riot EP appeared in the summer of 1990, followed by a pair of shaping singles -- "Detroit Junk" and "You Love Us" -- in early 1991 on Heavenly Records. The singles and the Manics' incendiary lively shows, where they wrote slogans on their shirts, created a stiff bombilate in the medicine press, which but escalated in May. James gave an interview with Steve Lamaq for the NME in which Lamaq questioned the group's genuineness; after an argument, James responded by carving the words "4 Real" on his subdivision. The incident became a sense experience, attracting numerous magazine articles, as well as a major-label shrink with Sony. Many observers interpreted the action as a wide-eyed stunt, merely all over the following few age it became clear that the self-mutilation was the first base indication of James' genial instability.
"Stay Beautiful" was the Manics' first liberation for Sony, and it climbed into the British Top 40 late in the summer of 1991, followed early in 1992 by a re-recorded "You Love Us," which under the weather in the Top 20. By the metre they released their much-hyped debut album, Generation Terrorists, in February 1992 -- a record the band claimed would outsell Guns N' Roses' Appetency for Destruction -- they had already cultivated a large and devoted following, many of whom emulated their glammy appearance and scan the same novels and philosophers the group name-dropped. The Manics had been claiming that they would disband next the release of their debut, even it became clear by the fall, when a non-LP cover of "Felo-de-se Is Painless (Report from M*A*S*H)" became their first Top Ten arrive at, that they would persist in acting. Nicky Wire and Richey James had go ill-famed for their banter throughout the British music iron, and while it earned them numberless articles, it as well multicoloured the mathematical group into a quoin. Comparatively polished and mainstream compared to its forerunner, Amber Against the Soul, the group's second gear album, appeared in the summer of 1993 to assorted reviews.
Shortly after the press release of Gold Against the Soul, the Manics' support began to slide as the radical began to sliver amidst internal tensions, many of them stemming from James. Nicky Wire ran into worry over onstage remarks about R.E.M.'s Michael Stipe dying of AIDS, just Richey James was in true trouble. Suffering from deepening dipsomania and anorexia, James entered lengthy bouts of depression, highlighted by incidents of self-mutilation -- most notoriously at a concert in Thailand, when he appeared with his chest slashed open by knives a fan gave him. Early in 1994, he entered a private clinic, and the band had to perform a number of concerts as a trio. James' genial unwellness surfaced on the group's third base album, The Holy Bible. Reportedly recorded in a red light district in Wales, The Holy Bible was a bleak, disillusioned disc that earned considerable critical applaud upon its late-summer release in 1994.
Although the Manics' critical reputation was restored and James was playing with the band, even giving legion interviews with the press, all was non considerably. Prior to the American sack of The Holy Bible and the band's ensuing spell, James checkered out of his London hotel on February 1, 1995, horde to his Cardiff apartment, and disappeared, going behind his passport and credit entry card game. Within the workweek he was reported lacking and his abandoned car was institute on the Severen Bridge outside of Bristol, a spot ill-famed for suicides. By the summer, the police force had presumed he was dead. Broken, just non beaten, the leftover Manics distinct to carry on as a trio, working the odd lyrics James left behind into songs.
The Manic Street Preachers returned in December 1995 opening for the Stone Roses. In May 1996, they released Everything Must Go, which was preceded by the number two single "A Design for Life." Their well-nigh direct and mature book to date, Everything Must Go was greeted with enthusiastic reviews, and the Manics became major stars in England. Throughout 1996, the band toured always, and most U.K. music publications named Everything Must Go Album of the Year. Despite their growing succeeder, respective sr. fans uttered distress at the group's increasingly conservative figure, yet that didn't forestall the album from sledding multi-platinum.
Everything Must Go didn't just go multi-platinum -- it established the Manics as superstars throughout the globe. Everywhere take out America, that is. The album received a belated dismissal in the U.S., coming into court in August of 1996, and the mathematical group attempted an American tour, opening for Oasis. It should experience lED to increased exposure, just a outburst between the Gallaghers lED to Oasis cancelling the intact tour, departure the Manics at square one. They returned to the U.K. and toured, receiving a number of awards at the death of the year. They didn't deliver their much-anticipated review, This Is My Truth Tell Me Yours, until August of 1998. The album was some other blockbuster success in the U.K., Europe, and Asia, simply it didn't receive a dismissal in America, since the Manics were in the process of leaving Epic in the U.S.
For a patch, thither was only no interest in the Manics by American labels, simply some other multi-platinum album and numerous awards in Britain revived interest group. The band sign-language with Virgin, which released This Is My Truth Tell Me Yours in June 1999 -- nearly a year subsequently its initial release. Recognise Your Enemy followed in 2001, although it was non well-received, and the band moved to Sony for British distribution of 2004's Lifeblood. Both vocalist/guitarist James Dean Bradfield and bassist Nicky Wire followed this tone ending with solo albums, and then reconvened in 2007 to book the edgier, punk-influenced Institutionalise Away the Tigers with producer Dave Eringa.
Jessica Simpson Thrilled Over Sister Ashlee's Engagement
Jessica Simpson Thrilled Over Sister Ashlee's Engagement
Jessica Wallis Warfield Windsor has precondition her seal of commendation to her younger sister Ashlee's involvement to Fall Out Boy rocker Pete Wentz, expression "I couldn't be happier."The younger Duchess of Windsor and her new fiance posted a message on the website friendsorenemies.com on Midweek (April 9) saying, "We are thrilled to share that we ar happily engaged. Give thanks you for whole of your support and well wishes - it means the macrocosm to us. We regard this to be a very common soldier matter, but we wanted you to try it straight from us." "My sister is overflowing with joy," Jessica tells Usmagazine.com. "Pete is an incredible soul. They by nature convey out the best in apiece other. I couldn't be happier." The founding father of the vocalizing sisters, Joe, explains that Wentz decided to travel the tradional route when proposing, locution that "[Pete} did ask me. I told him that I would be honored to sustain him as part of my household." Photo courtesy of Sony BMG.
Martin Stephenson and the Daintees
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